In this thesis, the terahertz methods, i.e. terahertz time-domain spectroscopy (THz-TDS) and terahertz pulsed imaging (TPI), were used as promising techniques to quantify the impact of the microstructure characteristics and formulation on the liquid transport process in two types of porous media, i.e. pharmaceutical and catalytic powder compacts. The terahertz methods were first used to investigate the liquid uptake and swelling in fast disintegrating tablets (FDTs) that were prepared from powder mixtures of either theophylline or paracetamol as a drug and either functionalised calcium carbonate (FCC) or microcrystalline cellulose (MCC) as a filler at different porosities. The terahertz results demonstrate the clear impact of porosity and formulation on the water transport and swelling kinetics of FDTs. The methodology was then extended to study the transport of water and 1-octanol in α-alumina powder compacts that were prepared at a range of different compaction forces, i.e. The terahertz results reveal that both the microstructure characteristics and surface properties have an impact on the liquid transport in the alumina compacts.ħ, 23, 40 and 58 kN, and heat treatment conditions, i.e.
The results show the great potential of the terahertz methods to study the liquid transport characteristics of polymeric and ceramic porous media. Quantifying the individual disintegration mechanisms, i.e. liquid ingress and swelling, is crucial for improving the design of pharmaceutical tablets through understanding the effect of raw materials and processing on the disintegration process. The information on the liquid transport in catalytic materials is also important for developing the design of catalysts and enhancing their performance upon contact with the liquid. Glidants play a vital role in tablet formulation.
Paracetamol granules were prepared to consist of either talc, colloidal silicon dioxide (CSD) or a combination of both This study aimed to examine the impact of glidants on theĬompaction and tableting properties of paracetamol granules prepared by wet granulation.
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